O069 The effects of sleep disordered breathing on sleep spindle activity in children and the relationship with neurocognition

Abstract Introduction Conventional sleep macro-architecture measures of disruption have not been associated with the adverse neurocognitive sequelae disordered breathing (SDB). Sleep spindles protecting sleeping brain from external sensory stimuli and can serve as markers integrity. We investigated relationship between fragmentation neurocognition across spectrum SDB in children. Methods Children 3-12y referred for clinical assessment age matched control children community were recruited. identified manually during N2 N3 sleep. Spindle activity was characterised spindle number, density (number spindles/ h) intensity (spindle x average duration). The Stanford-Binet Intelligence Scales measured global intellectual ability NeuroPSYchological (NEPSY-II) language, attention, visuospatial sensorimotor skills. Results grouped into control, Primary Snoring, Mild OSA Moderate/severe OSA, N=10/ group. All lower groups compared to Control this reached statistical significance (p<0.05 all). correlated any measure Stanford-Binet. Overall, all positively Design Copy Inhibition Naming combined scale score negatively Auditory Attention subscales NEPSY-II. Conclusion reduced observed SDB, particularly indicates that micro-architecture is disrupted may underpin negative effects on learning memory.